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I have used Ivermectin successfully for many years.

It prevents heartworms as well as
Mange Mites,
Hookworms,
Roundworms,
Whipworms,
ear mites
(NOT TAPEWORMS)
Does a fair job on fleas.

Dosage is:
Ivomec 1% (Cattle) liquid (There are 2 different strengths sold, so watch this when you buy)

Give 1cc for 10# body weigh ORALLY
Or
Give 0.1 cc per 1# body weight ORALLY - Must use 1cc TB Syringe

Once a week for 5 weeks, kills mites
Once a month- for Heartworms - (Main ingredient in Heartgard is IVOMEC)

Can use when puppies are 3-4 weeks old.
OK for pregnant and nursing mothers.
Some puppy breeders use at 4, 6 and 8 weeks for worming

You have to give a fairly large overdose to do any harm with Ivermectin.
It is known to be toxic to several herding breeds.
It can be given by injection Sub-Q if your dog won't take it orally.
Inject it into a hot dog and they'll usually gobble it without complaint.

There are also Ivermectin pastes for horses that some use for dogs. I haven't gone that route.

I think Ivermectin for my pack costs me about $7 a month, so it's a great money saver.